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Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.

Current allergy and asthma reports - 1 Oct 2012

Shah Neil, Kammermeier Jochen, Elawad Mamoun, Glocker Erik-Oliver

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (IL10R) deficiency present with IBD and demonstrate the...

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Gastrointestinal Tract
Hematopoietic Stem Cell Transplantation
Inflammatory Bowel Diseases
Interferon-gamma
Interleukin-10

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PMID: 22890722
DOI: 10.1007/s11882-012-0286-z

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