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Article

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside.

Clinical reviews in allergy & immunology - 26 Mar 2026

Xiao Jun, Ye Ziqing, Huang Ying

Abstract excerpt

Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. IL-10 receptor (IL-10R) consists of two chains of ligand-binding IL-10RA and two subunits of IL-10RB. IL-10 and IL-10R play important role in maintaining immune homeostasis in the gastrointestinal tract. Mutations in the IL10, IL10R cause spontaneous colitis in mice model and very early onset inflammatory bowel disease (VEOIBD) in human. Patients who...

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Inflammatory Bowel Diseases
Interleukin-10
Mutation
Signal Transduction

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41888292
DOI: 10.1007/s12016-026-09154-6
PMCID: PMC13021692

Genes

IL10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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