Article
A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease.
The Journal of clinical investigation - 1 Sept 2016
Zhou Vivian, Agle Kimberle, Chen Xiao, Beres Amy, Komorowski Richard, Belle Ludovic, Taylor Carolyn, Zhu Fenlu, Haribhai Dipica, Williams Calvin B, Verbsky James, Blumenschein Wendy, Sadekova Svetlana, Bowman Eddie, Ballantyne Christie, Weaver Casey, Serody David A, Vincent Benjamin, Serody Jonathan, Cua Daniel J, Drobyski William R
Abstract excerpt
Damage to the gastrointestinal tract is a major cause of morbidity and mortality in graft-versus-host disease (GVHD) and is attributable to T cell-mediated inflammation. In this work, we identified a unique CD4+ T cell population that constitutively expresses the β2 integrin CD11c and displays a biased central memory phenotype and memory T cell transcriptional profile, innate-like properties, and increased...
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