Article

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute <i>Clostridioides difficile</i> infection

2020-10-15

Abstract excerpt

Infection with the bacterial pathogen Clostridioides difficile causes severe damage to the intestinal epithelium that elicits a robust inflammatory response. Markers of intestinal inflammation accurately predict clinical disease severity. However, determining the extent to which host-derived proinflammatory mediators drive pathogenesis versus promote host protective mechanisms remains elusive. In this report, we...

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Literature Corpus work: 1deee2f0-82c3-5f56-9022-946751966bc8
DOI: 10.1101/2020.10.14.340190

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