Article

c-Maf-dependent regulatory T cells mediate immunological tolerance to intestinal microbiota

2017-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Both microbial and host genetic factors contribute to the pathogenesis of autoimmune disease 1-4 . Accumulating evidence suggests that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease (IBD), often also colonize healthy individuals. These microbes, including the Helicobacter species, have the propensity to induce autoreactive T cells and are collectively...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b81b323c-aa12-51ad-b0cb-3f914d48e956
DOI: 10.1101/129601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

c-Maf-dependent regulatory T cells mediate immunological tolerance to intestinal microbiotaDOI 10.1101/129601Read

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct ROR <i>γ</i> t <sup>+</sup> antigen presenting cell subsetSemantic proximity Read

Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cellsSemantic proximity Read

Type 3 regulatory T cells at the interface of symbiosisSemantic proximity Read

Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.Semantic proximity Read

Inflammation induced T <sub>h</sub> 17 cells synergize with the inflammation-trained microbiota to mediate host-resiliency against intestinal injurySemantic proximity Read

Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.Semantic proximity Read

Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression.Semantic proximity Read

Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitisSemantic proximity Read

Runx/Cbfβ regulates the development of tolerogenic Thetis cellsSemantic proximity Read

Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotasSemantic proximity Read

Immunopathogenesis of IBD: Batf as a Key Driver of Disease Activity.Semantic proximity Read

IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during ImmunotherapySemantic proximity Read