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Article

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.

Genes & development - 15 Sept 2004

Cheeseman Iain M, Niessen Sherry, Anderson Scott, Hyndman Francie, Yates John R, Oegema Karen, Desai Arshad

Abstract excerpt

Kinetochores play an essential role in chromosome segregation by forming dynamic connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore proteins from Caenorhabditis elegans, seven of which were previously uncharacterized. Using in vivo assays to monitor chromosome segregation, kinetochore assembly, and the mechanical stability of chromosome-microtubule attachments, we show...

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Source

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Identifiers

PMID: 15371340
DOI: 10.1101/gad.1234104
PMCID: PMC517519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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