Article
Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.
The Journal of cell biology - 7 Jun 2021
Doodhi Harinath, Kasciukovic Taciana, Clayton Lesley, Tanaka Tomoyuki U
Abstract excerpt
To establish chromosome biorientation, aberrant kinetochore-microtubule interaction must be resolved (error correction) by Aurora B kinase. Aurora B differentially regulates kinetochore attachment to the microtubule plus end and its lateral side (end-on and lateral attachment, respectively). However, it is still unclear how kinetochore-microtubule interactions are exchanged during error correction. Here, we...
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