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Article

Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

Science (New York, N.Y.) - 6 Dec 2013

Cheerambathur Dhanya K, Gassmann Reto, Cook Brian, Oegema Karen, Desai Arshad

Abstract excerpt

The microtubule-based mitotic spindle segregates chromosomes during cell division. During chromosome segregation, the centromeric regions of chromosomes build kinetochores that establish end-coupled attachments to spindle microtubules. Here, we used the Caenorhabditis elegans embryo as a model system to examine the crosstalk between two kinetochore protein complexes implicated in temporally distinct stages of...

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Identifiers

PMID: 24231804
DOI: 10.1126/science.1246232
PMCID: PMC3885540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.PMID 24231804Read ↗

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Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.Semantic proximity Read ↗

Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.Semantic proximity Read ↗

Cdc42 and mDia3 regulate microtubule attachment to kinetochores.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Coordination of NDC80 and Ska complexes at the kinetochore-microtubule interface in human cellsSemantic proximity Read ↗

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read ↗

A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

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