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Article

Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2015

Kudalkar Emily M, Scarborough Emily A, Umbreit Neil T, Zelter Alex, Gestaut Daniel R, Riffle Michael, Johnson Richard S, MacCoss Michael J, Asbury Charles L, Davis Trisha N

Abstract excerpt

Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism remains unclear. Here, we find that the conserved Mis12/MIND (Mtw1, Nsl1, Nnf1, Dsn1) and Ndc80...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26430240
DOI: 10.1073/pnas.1513882112
PMCID: PMC4611631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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