Article
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.
Molecular biology of the cell - 15 Apr 2011
Tooley John G, Miller Stephanie A, Stukenberg P Todd
Abstract excerpt
In kinetochores, the Ndc80 complex couples the energy in a depolymerizing microtubule to perform the work of moving chromosomes. The complex directly binds microtubules using an unstructured, positively charged N-terminal tail located on Hec1/Ndc80. Hec1/Ndc80 also contains a calponin homology domain (CHD) that increases its affinity for microtubules in vitro, yet whether it is required in cells and how the tail...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.