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Article

Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Sarangapani Krishna K, Akiyoshi Bungo, Duggan Nicole M, Biggins Sue, Asbury Charles L

Abstract excerpt

During mitosis, multiprotein complexes called kinetochores orchestrate chromosome segregation by forming load-bearing attachments to dynamic microtubule tips, and by participating in phosphoregulatory error correction. The conserved kinase Aurora B phosphorylates the major microtubule-binding kinetochore subcomplexes, Ndc80 and (in yeast) Dam1, to promote release of erroneous attachments, giving another chance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23589891
DOI: 10.1073/pnas.1220700110
PMCID: PMC3645574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.PMID 23589891Read ↗

Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.Semantic proximity Read ↗

The Ndc80 kinetochore complex directly modulates microtubule dynamics.Semantic proximity Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Structural plasticity of the living kinetochore.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments.Semantic proximity Read ↗

Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.Semantic proximity Read ↗

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

Metaphase kinetochore movements are regulated by kinesin-8 motors and microtubule dynamic instability.Semantic proximity Read ↗

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.Semantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensorsSemantic proximity Read ↗

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