Article

Coordination of NDC80 and Ska complexes at the kinetochore-microtubule interface in human cells

2019-10-28

Abstract excerpt

The conserved kinetochore-associated NDC80 complex (comprised of Hec1/Ndc80, Nuf2, Spc24, and Spc25) has well-documented roles in mitosis including (1) connecting mitotic chromosomes to spindle microtubules to establish force-transducing kinetochore-microtubule attachments, and (2) regulating the binding strength between kinetochores and microtubules such that correct attachments are stabilized and erroneous attac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2bca9797-556c-5816-90b2-9e31ce580074
DOI: 10.1101/820530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coordination of NDC80 and Ska complexes at the kinetochore-microtubule interface in human cellsDOI 10.1101/820530Read

Functional Interaction of SKA and NDC80 Complexes at Kinetochores Promoting Anaphase Onset in MitosisSemantic proximity Read

Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexesSemantic proximity Read

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read

Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of Hec1.Semantic proximity Read

Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.Semantic proximity Read

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.Semantic proximity Read

Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.Semantic proximity Read

Discrete regions of the kinesin-8 Kip3 tail differentially mediate astral microtubule stability and spindle disassembly.Semantic proximity Read

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.Semantic proximity Read

Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).Semantic proximity Read

Identification of two novel components of the human NDC80 kinetochore complex.Semantic proximity Read

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read