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Article

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.

eLife - 31 May 2018

Okumura Masako, Natsume Toyoaki, Kanemaki Masato T, Kiyomitsu Tomomi

Abstract excerpt

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery. However, in contrast to the chromosome-bound kinetochore structure, how the diffusion-prone cortical machinery is organized to generate large spindle-pulling forces remains poorly understood. Here, we develop a light-induced reconstitution system in human...

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PMID: 29848445
DOI: 10.7554/eLife.36559
PMCID: PMC6037482

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Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.PMID 29848445Read ↗

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensembleSemantic proximity Read ↗

Opposing motors provide mechanical and functional robustness in the human spindleSemantic proximity Read ↗

Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position.Semantic proximity Read ↗

Insights into human outer kinetochore assembly and force transmission from a structure-function analysis of the KMN networkSemantic proximity Read ↗

Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle sizeSemantic proximity Read ↗

Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.Semantic proximity Read ↗

Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolaritySemantic proximity Read ↗

Dynein is regulated by the stability of its microtubule track.Semantic proximity Read ↗

Torques within and outside the human spindle balance twist at anaphaseSemantic proximity Read ↗

High-resolution imaging reveals how the spindle midzone impacts chromosome movementSemantic proximity Read ↗

Coordinated poleward flux of sister kinetochore fibers drives chromosome alignmentSemantic proximity Read ↗

Requirements for NuMA in maintenance and establishment of mammalian spindle poles.Semantic proximity Read ↗

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