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Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis

7 Mar 2016

Abstract excerpt

The Huntington's disease (HD) protein, huntingtin (HTT), is essential for early development. Because suppressing the expression of mutant HTT is an important approach to treat the disease, we must first understand the normal function of Htt in adults versus younger animals. Using inducible Htt knockout mice, we found that Htt depletion does not lead to adult neurodegeneration or animal death at >4 mo of age,...

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PMID: 26951659
DOI: 10.1073/pnas.1524575113

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Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitisPMID 26951659Read ↗

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