Article

Striatal neuron excitability is regulated by huntingtin in the adult brain

2025-08-15

Abstract excerpt

Huntington’s disease (HD) is a hereditary neurodegenerative disease that typically presents during midlife and is characterized by a combination of motor, cognitive and psychiatric symptoms. HD is fatal and arises from a mutation in the huntingtin ( HTT ) gene, which results in decreased neuronal health followed by brain atrophy, with spiny projection neurons (SPNs) of the striatum being especially vulnerable to...

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Literature Corpus work: 941ccf39-393f-5171-901e-0c1c9e913dca
DOI: 10.1101/2025.08.14.670392

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