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Article

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.

PLoS genetics - 1 May 2016

Liu Xudong, Wang Chuan-En, Hong Yan, Zhao Ting, Wang Guohao, Gaertig Marta A, Sun Miao, Li Shihua, Li Xiao-Jiang

Abstract excerpt

The Huntington's disease (HD) protein, huntingtin (HTT), is a large protein consisting of 3144 amino acids and has conserved N-terminal sequences that are followed by a polyglutamine (polyQ) repeat. Loss of Htt is known to cause embryonic lethality in mice, whereas polyQ expansion leads to adult neuronal degeneration. Whether N-terminal HTT is essential for neuronal development or contributes only to late-onset...

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Identifiers

PMID: 27203582
DOI: 10.1371/journal.pgen.1006083
PMCID: PMC4874551

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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