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Article

Selective degeneration in YAC mouse models of Huntington disease.

Brain research bulletin - 30 Apr 2007

Van Raamsdonk Jeremy M, Warby Simon C, Hayden Michael R

Abstract excerpt

Huntington disease (HD) is one of at least nine polyglutamine disorders caused by a CAG expansion in the coding region of a disease-causing gene. These disorders are characterized by selective degeneration of different regions of the brain, which is not explained by the expression pattern of the mutant protein. In HD, degeneration primarily occurs in the striatum and cortex. To examine the mechanisms responsible...

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Identifiers

PMID: 17352936
DOI: 10.1016/j.brainresbull.2006.10.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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