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Article

Wild-type huntingtin plays a role in brain development and neuronal survival.

Molecular neurobiology - 1 Dec 2003

Reiner Anton, Dragatsis Ioannis, Zeitlin Scott, Goldowitz Daniel

Abstract excerpt

While the role of the mutated Huntington's disease (HD) protein in the pathogenesis of HD has been the focus of intensive investigation, the normal protein has received less attention. Nonetheless, the wild-type HD protein appears to be essential for embryogenesis, since deletion of the HD gene in mice results in early embryonic lethality. This early lethality is due to a critical role the HD protein, called...

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Identifiers

PMID: 14709789
DOI: 10.1385/MN:28:3:259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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