Article
Functions of huntingtin in germ layer specification and organogenesis.
PloS one - 1 Jan 2013
Nguyen Giang D, Molero Aldrin E, Gokhan Solen, Mehler Mark F
Abstract excerpt
Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explored. In order to better define the developmental functions and pathological consequences of the normal and mutant proteins,...
Topics
- Animals
- Cell Differentiation
- Ectoderm
- Embryoid Bodies
- Embryonic Stem Cells
- Endoderm
- Gene Knockout Techniques
- Germ Layers
- Huntingtin Protein
- Mesoderm
- Mice
- Mutation
- Nerve Tissue Proteins
- Neurogenesis
- Neurons
- Nuclear Proteins
- Oligodendroglia
- Organogenesis