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Article

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Cell - 16 Jun 2006

Graham Rona K, Deng Yu, Slow Elizabeth J, Haigh Brendan, Bissada Nagat, Lu Ge, Pearson Jacqueline, Shehadeh Jacqueline, Bertram Lisa, Murphy Zoe, Warby Simon C, Doty Crystal N, Roy Sophie, Wellington Cheryl L, Leavitt Blair R, Raymond Lynn A, Nicholson Donald W, Hayden Michael R

Abstract excerpt

Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase cleavage fragments represents an early pathological change in brains of Huntington's disease (HD) patients. However, the relationship between htt proteolysis and the pathogenesis of HD is unknown. To determine whether caspase cleavage of htt is a key event in the neuronal dysfunction and selective neurodegeneration in HD, we...

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Identifiers

PMID: 16777606
DOI: 10.1016/j.cell.2006.04.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.PMID 16777606Read ↗

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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.Semantic proximity Read ↗

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