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Article

Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreas.

Life science alliance - 1 Sept 2024

Bragg Robert M, Mathews Ella W, Grindeland Andrea, Cantle Jeffrey P, Howland David, Vogt Tom, Carroll Jeffrey B

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG tract in the huntingtin (HTT) gene, leading to toxic gains of function. HTT-lowering treatments are in clinical trials, but the risks imposed are unclear. Recent studies have reported on the consequences of widespread HTT loss in mice, where one group described early HTT loss leading to fatal pancreatitis, but later loss as...

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Identifiers

PMID: 39054288
DOI: 10.26508/lsa.202402571
PMCID: PMC11272958

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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