Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions.

Journal of Huntington's disease - 1 Jan 2024

Louessard Morgane, Cailleret Michel, Jarrige Margot, Bigarreau Julie, Lenoir Sophie, Dufour Noëlle, Rey Maria, Saudou Frédéric, Deglon Nicole, Perrier Anselme L

Abstract excerpt

Background: Mutations in the Huntingtin (HTT) gene cause Huntington's disease (HD), a neurodegenerative disorder. As a scaffold protein, HTT is involved in numerous cellular functions, but its normal and pathogenic functions during human forebrain development are poorly understood. Objective: To investigate the developmental component of HD, with a specific emphasis on understanding the functions of wild-type and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Induced Pluripotent Stem Cells

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 38427495
DOI: 10.3233/JHD-231509
PMCID: PMC11091579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions.PMID 38427495Read ↗

Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease.Semantic proximity Read ↗

Generation of New Isogenic Models of Huntington's Disease Using CRISPR-Cas9 Technology.Semantic proximity Read ↗

Use of human stem cells in Huntington disease modeling and translational research.Semantic proximity Read ↗

Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis.Semantic proximity Read ↗

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease.Semantic proximity Read ↗

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read ↗

HTT loss-of-function contributes to RNA deregulation in developing Huntington’s disease neuronsSemantic proximity Read ↗

HD mutation results in a dominant negative effect on HTT functionSemantic proximity Read ↗

Chromosomal instability during neurogenesis in Huntington's disease.Semantic proximity Read ↗

Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells.Semantic proximity Read ↗

Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.