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Article

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

Molecular and cellular biology - 1 Sept 2004

Trushina Eugenia, Dyer Roy B, Badger John D, Ure Daren, Eide Lars, Tran David D, Vrieze Brent T, Legendre-Guillemin Valerie, McPherson Peter S, Mandavilli Bhaskar S, Van Houten Bennett, Zeitlin Scott, McNiven Mark, Aebersold Ruedi, Hayden Michael, Parisi Joseph E, Seeberg Erling, Dragatsis Ioannis, Doyle Kelly, Bender Anna, Chacko Celin, McMurray Cynthia T

Abstract excerpt

Recent data in invertebrates demonstrated that huntingtin (htt) is essential for fast axonal trafficking. Here, we provide direct and functional evidence that htt is involved in fast axonal trafficking in mammals. Moreover, expression of full-length mutant htt (mhtt) impairs vesicular and mitochondrial trafficking in mammalian neurons in vitro and in whole animals in vivo. Particularly, mitochondria become...

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Identifiers

PMID: 15340079
DOI: 10.1128/MCB.24.18.8195-8209.2004
PMCID: PMC515048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.PMID 15340079Read ↗

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