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Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival

1 Jan 2020

Abstract excerpt

Huntington's disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of the striatal projection neurons (SPNs) of the striatum. HD is widely accepted to be caused by a toxic gain-of-function of mutant HTT. However, whether loss of HTT function,...

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PMID: 31968243
DOI: 10.1016/j.celrep.2019.12.069

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