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Article

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2002

Wellington Cheryl L, Ellerby Lisa M, Gutekunst Claire-Anne, Rogers Danny, Warby Simon, Graham Rona K, Loubser Odell, van Raamsdonk Jeremy, Singaraja Roshni, Yang Yu-Zhou, Gafni Juliette, Bredesen Dale, Hersch Steven M, Leavitt Blair R, Roy Sophie, Nicholson Donald W, Hayden Michael R

Abstract excerpt

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not been shown conclusively that htt is cleaved by caspases in vivo. Furthermore, no study has addressed when htt cleavage occurs with respect to the onset of neurodegeneration. Using antibodies that detect...

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PMID: 12223539
PMCID: PMC6758089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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