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Article

The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.

Cellular signalling - 1 May 2016

Hoa Lily, Kulaberoglu Yavuz, Gundogdu Ramazan, Cook Dorthe, Mavis Merdiye, Gomez Marta, Gomez Valenti, Hergovich Alexander

Abstract excerpt

By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the regulatory mechanisms of MST1/2-MOB1-LATS signalling are currently underinvestigated. Therefore,...

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Source

Identifiers

PMID: 26898830
DOI: 10.1016/j.cellsig.2016.02.012

Genes

LATS2
YAP1
MST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.PMID 26898830Read ↗

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