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Article

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Science signaling - 19 Nov 2013

Couzens Amber L, Knight James D R, Kean Michelle J, Teo Guoci, Weiss Alexander, Dunham Wade H, Lin Zhen-Yuan, Bagshaw Richard D, Sicheri Frank, Pawson Tony, Wrana Jeffrey L, Choi Hyungwon, Gingras Anne-Claude

Abstract excerpt

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network wi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24255178
DOI: 10.1126/scisignal.2004712

Genes

MST1
SLMAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24255178-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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