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Article

Down-regulation of LATS kinases alters p53 to promote cell migration.

Genes & development - 15 Nov 2015

Furth Noa, Bossel Ben-Moshe Noa, Pozniak Yair, Porat Ziv, Geiger Tamar, Domany Eytan, Aylon Yael, Oren Moshe

Abstract excerpt

p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in nontransformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53's conformation and transcriptional output toward a state resembling cancer-associated p53 mutants and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26588988
DOI: 10.1101/gad.268185.115
PMCID: PMC4691886

Genes

LATS1
LATS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Down-regulation of LATS kinases alters p53 to promote cell migration.PMID 26588988Read ↗

LATS tumor suppressor: A new governor of cellular homeostasisSemantic proximity Read ↗

The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.Semantic proximity Read ↗

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.Semantic proximity Read ↗

Identification of the kinase STK25 as an upstream activator of LATS signalingSemantic proximity Read ↗

STK25 directly activates LATS1/2 independent of MST/MAP4KsSemantic proximity Read ↗

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomasSemantic proximity Read ↗

The role of lats in cell cycle regulation and tumorigenesis.Semantic proximity Read ↗

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.Semantic proximity Read ↗

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.Semantic proximity Read ↗

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> PathwaySemantic proximity Read ↗

T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.Semantic proximity Read ↗

Plk1-mediated phosphorylation of Topors regulates p53 stability.Semantic proximity Read ↗

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