STK25 directly activates LATS1/2 independent of MST/MAP4Ks

Abstract excerpt

The Hippo pathway maintains tissue homeostasis by negatively regulating the oncogenic transcriptional co-activators YAP and TAZ. Though functional inactivation of the Hippo pathway is common in tumors, mutations in core pathway components are rare. Thus, understanding how tumor cells inactivate Hippo signaling remains a key unresolved question. Here, we identify the kinase STK25 as a novel activator of Hippo signa...

Topics

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• Calcium-Binding Proteins
• Cell Adhesion Molecules Research
• Cellular Mechanics and Interactions
• Crystallography, X-Ray
• Hippo pathway signaling and YAP/TAZ
• Molecular Docking Simulation
• Molecular Dynamics Simulation
• Protein Interaction Domains and Motifs

Identifiers and source

Literature Corpus work

83a6816a-125d-5387-94da-8dd84425f30e

DOI

10.1101/354233