Article
Co-occurring Mutations of Tumor Suppressor Genes, LATS2 and NF2, in Malignant Pleural Mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2017
Tranchant Robin, Quetel Lisa, Tallet Anne, Meiller Clement, Renier Annie, de Koning Leanne, de Reynies Aurelien, Le Pimpec-Barthes Francoise, Zucman-Rossi Jessica, Jaurand Marie-Claude, Jean Didier
Abstract excerpt
Purpose: To better define malignant pleural mesothelioma (MPM) heterogeneity and identify molecular subtypes of MPM, we focus on the tumor suppressor gene LATS2, a member of the Hippo signaling pathway, which plays a key role in mesothelial carcinogenesis.Experimental Design: Sixty-one MPM primary cultures established in our laboratory were screened for mutations in LATS2 Gene inactivation was modeled using...
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