T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.

doi:10.1016/j.lfs.2020.118655

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Article

T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.

Life sciences - 1 Jan 2021

Zhang Qin, Du Xiaotian, He Qiangqiang, Shi Wei, Mei Liu, Qv Meiyu, Tan Dan, Wu Junsong, Zeng Ling-Hui, Wu Ximei

Abstract excerpt

AIM: Large tumor suppressor 1 (LATS1) is a Ser/Thr kinase to mediate Hippo signaling pathway and plays a pivotal role in tumor suppression. By searching the COSMIC database, we found a somatic missense mutation (NM_004690.4:c.2552C>T) of human LATS1 (NP_004681.1:p.851T>I) in two colorectal cancer cell lines, and investigated the role and underlying mechanism of this mutation in the colorectal tumorigenesis. MAIN...

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Identifiers

PMID: 33141042
DOI: 10.1016/j.lfs.2020.118655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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