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Article

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> Pathway

15 Apr 2008

Abstract excerpt

The Hippo pathway defines a novel signaling cascade regulating cell proliferation and survival in Drosophila, which involves the negative regulation of the transcriptional coactivator Yorkie by the kinases Hippo and Warts. We have recently shown that the human ortholog of Yorkie, YAP, maps to a minimal amplification locus in mouse and human cancers, and that it mediates dramatic transforming activity in MCF10A...

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PMID: 18413746
DOI: 10.1158/0008-5472.can-07-6205

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Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> PathwayPMID 18413746Read ↗

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Implications for precision medicine and the reciprocal control of microRNAs by Hippo and TAZ signaling in breast cancerSemantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

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