Article

Inhibition of LATS Kinases in Ovarian Cancer Activates Cyclin D1/CDK4 and Decreases DYRK1A Activity

2022-12-10

Abstract excerpt

<h4>ABSTRACT</h4> The controlled division of cells requires a coordination of multiple cellular pathways. Hippo pathway controls the organ size and restricts cell proliferation in response to the signals from cell surface receptors, and genetic alterations in the components of this pathway are common in cancer. LATS1 and LATS2 are homologous protein kinases that relay the signals from the environment to the Hippo...

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Literature Corpus work: 0018186e-dc2c-51c1-a3cd-7d5fc74e9f6f
DOI: 10.1101/2022.12.06.519357

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