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Article

LATS tumor suppressor: A new governor of cellular homeostasis

1 Oct 2010

Abstract excerpt

Accumulating evidence points to the LATS (Large Tumor Suppressor) family of human tumor suppressors (LATS1 and LATS2) as new resident governors of cellular homeostasis. Loss of function of either LATS1 or LATS2 leads to a variety of tumor types including soft tissue sarcomas, leukemia, as well as breast, prostate, lung and esophageal cancers. Due to their high degree of homology and functional overlap, LATS1 and...

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Identifiers

PMID: 20935475
DOI: 10.4161/cc.9.19.13386

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Related research

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Research trail→

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LATS tumor suppressor: A new governor of cellular homeostasisPMID 20935475Read ↗

The role of lats in cell cycle regulation and tumorigenesis.Semantic proximity Read ↗

The NDR/LATS protein kinases in immunology and cancer biology.Semantic proximity Read ↗

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Identification of the kinase STK25 as an upstream activator of LATS signalingSemantic proximity Read ↗

T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.Semantic proximity Read ↗

The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.Semantic proximity Read ↗

WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer CellsSemantic proximity Read ↗

STK25 directly activates LATS1/2 independent of MST/MAP4KsSemantic proximity Read ↗

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.Semantic proximity Read ↗

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activitySemantic proximity Read ↗

Inhibition of LATS Kinases in Ovarian Cancer Activates Cyclin D1/CDK4 and Decreases DYRK1A ActivitySemantic proximity Read ↗

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.Semantic proximity Read ↗

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