Article
Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.
Structure (London, England : 1993) - 5 Mar 2013
Shi Zhubing, Jiao Shi, Zhang Zhen, Ma Miao, Zhang Zhao, Chen Cuicui, Wang Ke, Wang Huizhen, Wang Wenjia, Zhang Lei, Zhao Yun, Zhou Zhaocai
Abstract excerpt
Mammalian STE20-like kinase MST4 regulates multiple cellular aspects such as cell polarity and proliferation. MST4 acts downstream of LKB1/MO25/STRAD complex to induce brush border formation. MO25 directly interacts with MST4 to promote its kinase activity. Here, we report the crystal structure of MST4 in complex with MO25. Association of MO25 rotates the αC helix of MST4 toward its catalytic core, stabilizing...
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