Article

Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired tumor suppressor activities

2024-01-05

Abstract excerpt

<title>Abstract</title> <p>Mammalian Ste-20-like Kinases 1 and 2 (MST1/2) are core serine-threonine kinases of the Hippo pathway regulating several cellular processes, including cell cycle arrest and cell death. Here, we discovered a novel alternative splicing variant of the MST2 encoding gene, <italic>STK3</italic>, in malignant cells and tumor datasets. This variant, named <italic>STK3</italic><sup><italic>∆7</...

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Literature Corpus work: 66d782f1-7319-51e9-bc6a-93095aa36d34
DOI: 10.21203/rs.3.rs-3740673/v1

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