Article

Clinical and Therapeutic Applications of Individual-level Tissue-Specific Imputed Transcriptomes

2022-11-28

Abstract excerpt

Gene expression causally contributes to phenotypic variability. However, since tissue-specific gene expression is difficult to measure at scale, inferring phenotypic risk for individuals using expression profiles can be difficult. We statistically imputed tissue-specific gene expression for 486,452 UK Biobank participants and demonstrated its applications using rich phenotypic data in the biorepository. We perform...

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Literature Corpus work: fc8a22b5-373a-5f99-9450-0df3ad88d054
DOI: 10.1101/2022.11.23.22282644

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