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Article

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits.

PLoS genetics - 1 May 2023

Evans Luke M, Arehart Christopher H, Grotzinger Andrew D, Mize Travis J, Brasher Maizy S, Stitzel Jerry A, Ehringer Marissa A, Hoeffer Charles A

Abstract excerpt

It remains unknown to what extent gene-gene interactions contribute to complex traits. Here, we introduce a new approach using predicted gene expression to perform exhaustive transcriptome-wide interaction studies (TWISs) for multiple traits across all pairs of genes expressed in several tissue types. Using imputed transcriptomes, we simultaneously reduce the computational challenge and improve interpretability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37216417
DOI: 10.1371/journal.pgen.1010693
PMCID: PMC10237671

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