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Article

A gene-based association method for mapping traits using reference transcriptome data.

Nature genetics - 1 Sept 2015

Gamazon Eric R, Wheeler Heather E, Shah Kaanan P, Mozaffari Sahar V, Aquino-Michaels Keston, Carroll Robert J, Eyler Anne E, Denny Joshua C, Nicolae Dan L, Cox Nancy J, Im Hae Kyung

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general, not well understood. We propose a gene-based association method called PrediXcan that directly tests the molecular mechanisms through which genetic variation affects phenotype. The approach estimates the component of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26258848
DOI: 10.1038/ng.3367
PMCID: PMC4552594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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