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Article

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits.

American journal of human genetics - 2 Mar 2017

Mancuso Nicholas, Shi Huwenbo, Goddard Pagé, Kichaev Gleb, Gusev Alexander, Pasaniuc Bogdan

Abstract excerpt

Although genome-wide association studies (GWASs) have identified thousands of risk loci for many complex traits and diseases, the causal variants and genes at these loci remain largely unknown. Here, we introduce a method for estimating the local genetic correlation between gene expression and a complex trait and utilize it to estimate the genetic correlation due to predicted expression between pairs of traits....

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Identifiers

PMID: 28238358
DOI: 10.1016/j.ajhg.2017.01.031
PMCID: PMC5339290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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