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Article

Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2016

Foti Alessandro, Hartmann Tobias, Coelho Catarina, Santos-Silva Teresa, Romão Maria João, Leimkühler Silke

Abstract excerpt

Aldehyde oxidase (AOX1) is an enzyme with broad substrate specificity, catalyzing the oxidation of a wide range of endogenous and exogenous aldehydes as well as N-heterocyclic aromatic compounds. In humans, the enzyme's role in phase I drug metabolism has been established and its importance is now emerging. However, the true physiologic function of AOX1 in mammals is still unknown. Further, numerous...

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Source

Identifiers

PMID: 26842593
DOI: 10.1124/dmd.115.068395

Genes

AOX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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