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Article

A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.

PloS one - 1 Jan 2017

Foti Alessandro, Dorendorf Frank, Leimkühler Silke

Abstract excerpt

Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. The enzymes use oxygen as the terminal electron acceptor and produce reduced oxygen species during turnover. The physiological function of mammalian AOX isoenzymes is still unclear, however,...

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Identifiers

PMID: 28750088
DOI: 10.1371/journal.pone.0182061
PMCID: PMC5531472

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Source receipt: pubmed, retrieved 7 Sept 2026.

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