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Article

Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.

Archives of biochemistry and biophysics - 15 Aug 2007

Penning Trevor M, Drury Jason E

Abstract excerpt

Aldo-keto reductases (AKRs) are a superfamily of NAD(P)H linked oxidoreductases that are generally monomeric 34-37kDa proteins present in all phyla. The superfamily consists of 15 families, which contains 151 members (www.med.upenn.edu/akr). Thirteen human AKRs exist that use endogenous substrates (sugar and lipid aldehydes, prostaglandins, retinals and steroid hormones), and in many instances they regulate...

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Identifiers

PMID: 17537398
DOI: 10.1016/j.abb.2007.04.024
PMCID: PMC2025677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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