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Article

Polymorphisms of Human Aldehyde Dehydrogenases

1 Jan 2000

Abstract excerpt

Aldehyde dehydrogenases (ALDHs), a superfamily of NAD(P)(+)-dependent enzymes with similar primary structures, catalyze the oxidation of a wide spectrum of endogenous and exogenous aliphatic and aromatic aldehydes. Thus far, 16 ALDH genes with distinct chromosomal locations have been identified in the human genome. Polymorphism in ALDH2 is associated with altered acetaldehyde metabolism, decreased risk of...

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PMID: 10971205
DOI: 10.1159/000028400

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