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Article

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.

Current opinion in chemical biology - 1 Apr 2017

Romão Maria João, Coelho Catarina, Santos-Silva Teresa, Foti Alessandro, Terao Mineko, Garattini Enrico, Leimkühler Silke

Abstract excerpt

Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. Mammals are characterized by a complement of species-specific AOX isoenzymes, that varies from one in humans (AOX1) to four in rodents (AOX1, AOX2, AOX3 and AOX4). The physiological function of...

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Source

Identifiers

PMID: 28126656
DOI: 10.1016/j.cbpa.2017.01.005

Genes

AOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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