Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.

doi:10.1016/j.cbpa.2017.01.005

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Article

Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.

Current opinion in chemical biology - 1 Apr 2017

Romão Maria João, Coelho Catarina, Santos-Silva Teresa, Foti Alessandro, Terao Mineko, Garattini Enrico, Leimkühler Silke

Abstract excerpt

Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. Mammals are characterized by a complement of species-specific AOX isoenzymes, that varies from one in humans (AOX1) to four in rodents (AOX1, AOX2, AOX3 and AOX4). The physiological function of...

Topics

Aldehyde Oxidase
Animals
Enzyme Inhibitors
Humans
Mammals
Pharmaceutical Preparations
Polymorphism, Single Nucleotide
Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 28126656
DOI: 10.1016/j.cbpa.2017.01.005

Genes

AOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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