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Article

The impact of single nucleotide polymorphisms on human aldehyde oxidase.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2012

Hartmann Tobias, Terao Mineko, Garattini Enrico, Teutloff Christian, Alfaro Joshua F, Jones Jeffrey P, Leimkühler Silke

Abstract excerpt

Aldehyde oxidase (AO) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. AO is active as a homodimer, and each 150-kDa monomer binds two distinct [2Fe2S] clusters, FAD, and the molybdenum cofactor. AO has an important role in the metabolism of drugs based on its broad substrate specificity oxidizing aromatic aza-heterocycles, for example, N(1)-methylnicotinamide and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22279051
DOI: 10.1124/dmd.111.043828
PMCID: PMC4738704

Genes

AOX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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