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Structure of human aldehyde oxidase under tris(2-carboxyethyl)phosphine-reducing conditions

2026-03-25

Abstract excerpt

The importance of human aldehyde oxidase (hAOX1) has increased over the last decades due to its involvement in drug metabolism. Inhibition studies concerning hAOX1 are extensive and a common reducing agent, dithiothreitol (DTT), was recently found to inactivate the enzyme. However, in previous crystallographic studies of hAOX1, DTT was found to be essential for crystallization. To surpass this concern another redu...

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Literature Corpus work
d9961442-639e-5d04-baab-67a82f62a10a
DOI
10.64898/2026.03.25.713928
Open publication

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Structure of human aldehyde oxidase under tris(2-carboxyethyl)phosphine-reducing conditionsDOI 10.64898/2026.03.25.713928
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