Article
The TT allele of rs405509 synergizes with APOE ε4 in the impairment of cognition and its underlying default mode network in non-demented elderly.
Current Alzheimer research - 1 Jan 2016
Ma Chao, Zhang Yangjun, Li Xin, Chen Yaojing, Zhang Junying, Liu Zhen, Chen Kewei, Zhang Zhanjun
Abstract excerpt
BACKGROUND: Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD). However, it is unclear the APOE-rs405509 interaction effect on brain spontaneous activity. METHODS: We analyzed the interaction of the rs405509 TT allele and the APOE ε4 allele on cognitive performances measured using...
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