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Article

The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly.

Molecular neurobiology - 1 Feb 2018

Liu Zhen, Dai Xiangwei, Zhang Junying, Li Xin, Chen Yaojing, Ma Chao, Chen Kewei, Peng Dantao, Zhang Zhanjun

Abstract excerpt

The PICALM rs541458 T allele has been recognized as a risk factor for late-onset Alzheimer's disease, and age might modulate the effects that genetic factors have on cognitive functions and brain. Thus, the current study intended to examine whether the effects of rs541458 on cognitive functions, brain structure, and function were modulated by age in non-demented Chinese elderly. We enrolled 638 subjects aged 50...

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Source

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Identifiers

PMID: 28116548
DOI: 10.1007/s12035-016-0358-5
PMCID: PMC5820373

Genes

PICALM
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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