APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network.

doi:10.1111/cns.13716

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Article

APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network.

CNS neuroscience & therapeutics - 1 Nov 2021

Zang Feifei, Zhu Yao, Zhang Qianqian, Tan Chang, Wang Qing, Xie Chunming

Abstract excerpt

AIMS: This study aims to investigate the mechanisms by which apolipoprotein E (APOE) genotype modulates the relationship between low-density lipoprotein receptor-related protein 1 (LRP1) rs1799986 variant on the default mode network (DMN) and cognition in Alzheimer's disease (AD) spectrum populations. METHODS: Cross-sectional 168 subjects of AD spectrum were obtained from Alzheimer's Disease Neuroimaging...

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Identifiers

PMID: 34387022
DOI: 10.1111/cns.13716
PMCID: PMC8504518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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